The railway line to St Marys opened in May 1862, with the original station being a siding. The waiting room to the central platform and the parcels office are both brick. The parcel office features semicircular window arches, and heavy timber doors and lintels. Cattle saleyards and saw mills surrounded the station, providing easy access to the railway line. The station was originally named South Creek but was renamed St Marys in August 1885.
